Arthritis in cats: a tale of biotech and a Chinese hamster

Posted on January 30, 2022 by felinepurrspective_u3q4o6

If you search for “monoclonal antibodies”, most of the search results are about COVID-19 and its variants. But did you know that monoclonal antibodies form the basis of the newest treatment for arthritis in cats? This new treatment is called Solensia. Solensia is a monthly injection for arthritic cats that won FDA approval this month. It should be available through your veterinarian later this year.

arthritis in cats: a tale of biotech and a chinese hamster

what are monoclonal antibodies?

Monoclonal: refers to a cell or organism that comes from a single individual or cell.
Antibodies are proteins in the blood that our immune system produces to counteract a foreign substance such as a bacteria or virus (think COVID-19).

antibodies and the immune system

Immune cells in our bodies called B-lymphocytes mount a response to a foreign substance or antigen (e.g. a virus), binding to it and deactivating it. The presence of the antigen and immune cells called T cells activate the B-cells. The B cells then propagate and release antibodies that are able to bind to and deactivate the specific antigen that stimulated their formation!

Monoclonal antibodies are derived from clones or copies of activated B cells. They can be harvested and grown in the laboratory and used to fight infections caused by the antigen they were developed to target.

Where do monoclonal antibodies come from?

Blood cells from convalescing patients: Due to the large numbers of convalescing COVID patients, there was a ready source of blood cells containing B-cells with antibodies to COVD 19 that could be used to make monoclonal antibodies to treat newly infected patients.
Transgenic mice: Mice that have been genetically altered to carry human antibody genes instead of mouse antibody genes are the usual source for monoclonal antibodies. These mice can be injected with a specific antigen and produce fully human antibodies that can be used by human patients to combat that antigen. Being human antibodies, they are less likely to be rejected by the human immune system.

Arthritis in cats: using monoclonal antibodies

Nerve growth factor (NGF) is a protein that is key to the development and survival of nerve cells or neurons, particularly sensory neurons that transmit pain, temperature, and touch sensations.

When NGF binds to pain receptors inside the sensory neuron, a series of events is triggered that ultimately sends a “pain” signal to the brain.

Instead of binding to a structure on a virus, monoclonal antibodies can be developed to recognize and attach to NGF, preventing NGF from binding to the pain receptors on the sensory neruron, blocking the pain signal.

Motion is Medicine

A reduction in pain means our arthritic cats will be more likely to move around more. Increased mobility will strengthen the cat’s muscles, so they can better support and assist the deteriorating joints. Increased activity and reduced pain result in a better quality of life.

Biotech Magic

The active ingredient in Solensia is frunevetmab, a monoclonal antibody that targets NGF. The antibodies are sourced from Chinese hamster ovary cells. Like the mice that have human antibodies instead of mouse antibodies, the hamster cells are “felinised”using recombinant biotechnology. Sections of the hamster antibodies are replaced with their feline counterparts. “Felinization” ensures that the cat’s immune system will not reject the monoclonal antibodies but allow them to function as part of the cat’s immune system.

Of cats and hamsters: no hamsters harmed

Frunevetmab is sourced from the cells of Chinese hamster ovaries. In fact, cells from an individual Chinese hamster, harvested back in the 1950s, produced the cell line which dominates biotechnology today. These cells are easy to propagate and maintain in the lab, providing a ready source of monoclonal antibodies.

multimodal therapy for arthritis in cats

Solensia is a pain medication and does not directly aid in preserving the synovial tissues. Most likely, Solensia will be part of a multimodal treatment that will include drugs and supplements like Adequan or glucosamine that are thought to help maintain synovial tissues in addition to weight loss and exercise.

Unlike other arthritis pain treatments such as NSAID’s, monoclonal antibodies are eliminated in the same way other proteins are, with minimal effect on the kidneys and liver, a concern for our cats with Chronic Kidney Disease.

Treatment using Solensia will consist of monthly injections under the skin. Most cat owners can become proficient in giving subcutaneous injections and treatment can be done in the safety and comfort of the cat’s home.

Thanks to a Chinese hamster years ago and advances in biotechnology, our cats may be able to spend their “ golden years” without pain from osteoarthritis!

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Arthritis Supplements for cats – do they work?

Posted on December 19, 2021 by felinepurrspective_u3q4o6

A cat receives an injection of polysulfonated glycosaminoglycans.

It is thought that almost 40% of all cats have clinical signs of arthritis and 90% of cats over age 12 have damage to the joints that you can see on x-rays. Cats are such masters at hiding pain that we are now thinking that arthritis is there earlier, pain is happening and we may not be able to see it on x-rays yet.

What if we could be proactive and start some kind of treatment before our cats even seem painful? Could we slow the deterioration of the joints? What arthritis supplements for cats are available and do they work?

The motivation behind writing this post was to help my youngest cat, 5 year old Gus, who showed some indications of spinal arthritis in his x-rays. Should I begin a supplement with him? I was astounded by the sheer numbers of arthritis supplements for cats on the market and the astounding claims they made.

arthritis supplements for cats – do they work?

Arthritis supplements for cats on the market now range from supplements used by humans to homeopathic remedies. Clinical trials are rare to non-existent on many of these products. This post addresses the more common products and ones that have had some double-blinded clinical studies done.

glucosamine/chondroitin,
omega fatty acids/ green lipped mussel extract
polysulfated glycosaminoglycans

Glucosamine/chondroitin

Glucosamine occurs naturally in cartilage, the flexible connective tissue found throughout the body – for example, in the external ears and the surfaces of joints. The supplement can be made synthetically in the lab or harvested from the shells of shellfish.

Some human studies have shown oral glucosamine may help with pain relief and slowing of joint degeneration in people suffering from osteoarthritis. However, in general, the results from these studies are not conclusive.

Dasuquin is a commercially available formulation of glucosamine/chondroitin for cats. It is a dietary supplement in a capsule that is sprinkled on food. The product has been evaluated for safety.

A recent double-blinded study of Dasuquin enrolled 59 cats with Degenerative Joint Disease.

All 59 cats were given a placebo for 2 weeks.
Then 29 cats received the supplement for 6 weeks while another 30 continued to receive the placebo.
The cats were evaluated by using an at-home accelerometer (like a kitty “fit bit”), owner observations and vet exams through out the study.
The study showed a strong placebo effect – 78% of the cats were more active while on the placebo.
Cats on the supplement did not show any statistically significant improvement over cats on the placebo.

However, the study did raise some questions:

The “kitty fit-bits” showed that the least active cats at the start of the study became more active on the supplement. Were these cat more painful to begin with?
The placebo was given in the first two weeks of the study when owner enthusiasm would have understandably been highest and owners would have been looking for improvement.

More research is needed – perhaps a different study design?

Omega Fatty acids (fish oils)

Supplementation with fish oils has shown some benefit for arthritic cats. A double-blinded study showed that cats supplemented with fish oil for 10 weeks were more active, going up and down the stairs more, jumping higher, not walking as stiffly and were more interactive with their people. This study used owner evaluation to assess the cats’ improvement.

Fish oil can be given as a dietary supplement (Welactin) or fed as a therapeutic diet, such as Hill’s j/d.

Side effects of fatty acid supplementation include GI upset and reduced blood clotting. There is some controversy over how much fish oil is enough. Additionally, fish oil can add quite a bit of calories to your cat’s diet and could result in weight gain, taxing your cat’s joints further.

Merial’s Antinol for Cats supplement is based on fatty acids from green-lipped mussel extract. There are a number of case studies where the supplement has been given to cats with good results for cardiac and dermatological issues, in addition to joint and mobility problems.

Polysulfated Glycosaminoglycans (PSGAGs)

This product is available under the brand name Adequan. It is the veterinary version of Arteparon, used in humans.

Decreases the breakdown in cartilage. The PSGAG’s allows the cartilage to hold more water, making it resistant to degradation.
Adequan has been extensively studied in dogs and horses for over 20 years and is FDA-approved for these species
Available by prescription.
Given by subcutaneous injection in cats with generally good results.

The jury is still out on most of the arthritis supplements for cats. Given at the manufacturer’s recommended dose, these products are safe and may be effective. Considering the individual nature of pain, some cats may respond favorably while others do not. Once again supplements are basically unapproved drugs so there is not the rigorous evaluation that accompanies FDA approval.

Your vet is your best resource on arthritis supplements for cats. He or she will be able to recommend a supplement or diet that is appropriate for your cat and is compatible with other medications or medical conditions your cat may have. In particular, combining supplements should be done with care – glucosamine, fatty acids and Adequan all effect how your cat’s blood clots.

So, what will I do for Gus?

My vets recommended the Adequan injection, citing the robustness of the canine studies and the fact that it is an injection – there is a greater confidence that the cat will get the supplement. We are not depending on him to eat something.

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Measuring your cat’s blood pressure: why and how

Posted on December 12, 2021 by felinepurrspective_u3q4o6

HDO BP cat — A cat relaxes in his basket during a blood pressure reading at home using an HDO unit. The cuff is on his tail. The blood pressure wave is on the computer screen.

You’ve brought your senior cat in for her regular checkup and the technician asks you if you would like to have her blood pressure checked. Although your blood pressure is routinely checked when you go to the doctor, it has not occurred to you to ask to have your cat’s blood pressure checked. Should you have your cat’s blood pressure measured? How is it done – will it be uncomfortable? Frightening?

Why measure your cat’s blood pressure

As cats age, many develop hyperthyroidism and kidney disease. Other cats may develop diabetes. All of these conditions can result in the heart pumping harder to compensate for the changes. As the heart pumps harder, blood pressure increases and arteries, the eyes, the kidneys, the brain and heart can be damaged.

Left untreated, high blood pressure can result in:

blindness
increasing loss of protein through the kidneys >> shortened life span
disorientation, lack of balance, seizures, altered mentation or behavior, or weakness in the limbs

The best way to avoid these consequences is to monitor your cat’s blood pressure and start treatment if his blood pressure is high.

So how do we measure your cat’s blood pressure?

When measuring blood pressure in humans, we typically place a pressure cuff on the upper arm, inflate the cuff until the flow of blood to the artery is shut off . The cuff is then released, and a wave of blood fills the artery, turbulent at first, then subsiding to a smooth flow.

The human practitioner can use a stethoscope to listen to the sounds made as the blood rushes back into the artery.

The first sound is heard at the systolic blood pressure (the higher number in 120/80)
The final sound is heard at the diastolic pressure (the lower number in 120/80).

We will also use a blood pressure cuff to measure your cat’s blood pressure. This cuff can be put:

on the front leg
on the hind limb, above or below the hock (ankle)
on the tail

Cats’ arteries are much smaller than humans’ and it is difficult to hear the sounds of the blood flow using a stethoscope, so we turn to other methods: Doppler and oscillometric.

Doppler

A Doppler unit measures blood flow.

After placing the cuff on your cat, the Doppler sensor is placed over the target artery.
Piezoelectric crystals in the sensor detect changes in the flow of blood in the arteries and convert these to sound.
Acoustic gel on the sensor ensures good contact so that the practitioner can hear the heartbeat.
The cuff is inflated until the heartbeat is no longer heard.
The cuff is then released and the pressure at which the heartbeat can be heard again is the systolic blood pressure.
Headphones are usually used when measuring blood pressure with a Doppler.

Doppler units give us a measurement of the systolic blood pressure, the larger number in the 120/80.

Oscillometric

Only a cuff needs to be placed to measure your cat’s blood pressure with an oscillometric unit.

A sensor in the cuff detects the pressure pulses in the artery.
As the cuff is inflated, the pulses decrease as flow to the artery is cut off.
The cuff is then deflated and the pressure wave that results as the blood rushes back into the artery is analyzed.

Oscillometric units typically only measure the peak of this wave, the average blood pressure, and calculate the systolic and diastolic pressures.

A High Definition Oscillometric unit records the entire pressure wave, directly measuring the systolic and diastolic pressures. An HDO unit is usually connected to a computer to view the pressure wave and determine if the measurement was accurate.

How accurate is a blood pressure if my cat is nervous at the vet clinic?

Just like people, cats get anxious and nervous when visiting the vet clinic. Blood pressure is sensitive to this and it can be a challenge to measure your cat’s blood pressure.

Putting the odds in our favor:

Most of the time, you should be with your cat during a blood pressure measurement. Your cat knows you and trusts you. Your presence is reassuring and calming.
Allow your cat to settle in for 5-10 minutes – the measurement should be done in a quiet room.
If your cat likes to snuggle in your lap, see if the measurement can be done there. If your cat prefers to sit on his stomach, perhaps a tail measurement is best. If he is comfortable laying on his side, a hind leg may be better.
Using the front leg to measure blood pressure puts the practitioner in front of the cat; curious cats may want to take a nibble at the blood pressure cuff. I prefer that your cat be facing you, her person, who can reassure her. I feel the tail and hind leg work better.
The artery being measured, tail or hind leg, should be at the same level as the heart – so kitty should not be sitting up, but laying comfortably on his stomach or side.

What do the numbers mean?

Again, like people, the systolic pressure is ideally around 120.
Pressures 150 and over can indicate the need for medication.
Your vet may also do an eye exam, looking at the eye with an ophthalmoscope or lens. In some instances of high blood pressure, the vessels in the eye dilate and become twisted; sometimes the retina may be detached, resulting in blindness. If high blood pressure is caught early enough, blindness may resolve with treatment.

My cat’s blood pressure is high but her eyes looked OK. What next?

High blood pressure can be treated with drugs – the most common drug used is oral amlodipine. Amlodipine takes effect fairly quickly and a blood pressure can be repeated in about 10 days and the dose adjusted if needed.
Other medications such as benazepril or telmisartan may be used alongside or in place of amlodipine.

I don’t think the reading was accurate – my cat was too nervous

It is worth investing in a home blood pressure visit. A practitioner can come to your home and get a measurement where your cat feels safe and secure.

Measuring your cat’s blood pressure especially as she gets older will help keep her healthy and comfortable. Without treatment, high blood pressure can have serious side effects, including blindness, seizures, and cardiac damage.

Have your cat examined regularly by your veterinarian, as changes to the eyes or a heart murmur might warrant a blood pressure check.

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Cat dementia – Three cats and three outcomes

Posted on November 14, 2021 by felinepurrspective_u3q4o6

Identifying signs of cat dementia is not always straightforward. In the hubbub of daily life, behavior changes can be subtle and go unnoticed until they are more severe.

Changes in behavior can indicate if your cat’s mental state has changed. The acronym VISHDAAL summarizes the behavior changes we need to observe to care for our senior cats.

V = changes or increase in vocalization
I = changes in interaction with us and other pets
S = changes in sleep-wake cycle: restlessness, night time activity
H = housesoiling
D = disorientation and confusion
A = changes in activity
A = anxiety
L = learning and memory

Three cats – three outcomes

rupert, 18 year old neutered male siamese

I had two senior Siamese cats when I had my first child. A first-time mom, I was frazzled, dealing with the completely new experience of parenting and was not paying as much attention as I should have to my cats.

One day, an acquaintance asked why one of the cats, Rupert, was sitting on the kitchen counter, in a corner, facing the wall. I had been aware that he did that sometimes but when I paid closer attention, I found that he would eat in the morning, use his litter box and then spend the day on the counter, facing the wall. He would come down to eat, drink, and use the litter box but always returned to the counter.

Behavior Changes – signs of cat dementia?

I – Rupert was no longer interacting with us.
D – He seemed confused and “out of it” – sitting on the counter all day
A – His activity had changed – he did not move much from the counter

Diagnosis:

Rupert had lost quite a bit of weight, although he was eating well. My vet diagnosed him with hyperthyroidism, which was a new disease in cats at that time.

Outcome:

Use of radioactive iodine to treat the disease was pioneered about 10 years earlier but it was not commonplace. Surgery was an option but at 18 years of age, Rupert was not a good candidate for surgery and we elected euthanasia due to his declining Quality of Life.

The Takeway:

I suspect that Rupert had moderate to severe cat dementia. The symptoms were most likely apparent earlier and I just did not recognize them. Nowadays, drug therapy for hyperthyroidism is readily available – methimazole is an FDA approved treatment for hyperthyroid cats. Perhaps treatment of the hyperthyroidism would have reduced the symptoms of cat dementia enough for Rupert to have had some more time with us.

Athena, 16 year old spayed female

Athena had been slowing down over the past year, was not eating as well and was spending most of her time sleeping. We had provided her with steps to access window perches and our bed; we also provided her with a heated bed.

Behavior Changes – signs of cat dementia?

I – Although still willing to play, Athena was interacting less with us; she had previously been a “nosy, busybody” kind of cat.
A – Athena no longer went on her daily walk and was less active in general

Diagnosis:

Diagnostic blood work did not show any significant changes over the past year. Athena did not show other signs of cat dementia and would still learn new tricks when hungry for treats.

X-rays showed moderate to severe arthritis in one of her hips and knees. We decided to treat her arthritis pain with the drug gabapentin.

Outcome:

Treatment for her arthritis pain has been a game changer for her; her activity level has increased, her appetite has increased, and she is back to “being in your face” when she wants something.

The Takeaway:

Regular checkups and treatment of chronic conditions can make you and your cat happier! Some symptoms typical of dementia may be due to treatable, medical conditions.

Marley, 15 year old neutered male

cat with food puzzle — Marley works the Poker Box, a food puzzle.

Marley is a friendly, affectionate cat with good health overall. In the past several months, Marley showed some of the behavior changes that we need to monitor in senior cats.

Behavior Changes – signs of cat dementia?

I – Marley had become more clingy than usual and more interactive
D – He seemed confused when playing the nightly game of “treat toss” – he seemed to forget that he was chasing a treat!
A – He did not want to walk outside with us (which he has been doing for years).
A – He seemed anxious and a little fearful. His interactions with the other cats became timid.

Diagnosis

Marley’s senior exam and blood work did not reveal any abnormalities other than a slight decline in kidney function which could be expected at his age.

Marley appears to have some mild cat dementia. Since these changes were mild, we decided to try SAMe, a dietary supplement. SAMe has been shown to be effective at reducing symptoms of dementia in cats in the early stages of cat dementia.

Outcome

About 2 months have gone by with daily supplementation. Marley is taking his daily walk again and is not as clingy with his humans. He is no longer stand-offish with the other cats and is “catching” his treats again when we play the nightly treat toss.

A Final Word…

Cat dementia cannot be cured but it can be managed. With early diagnosis, appropriate environmental modifications, dietary supplements, therapeutic diets, and medication can help can reduce the symptoms of dementia and improve Quality of Life for both you and your cat.

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Cat dementia: How can we manage it?

Posted on November 7, 2021 by felinepurrspective_u3q4o6

At the veterinary clinic where I work, I often hear people say when I ask about their cat’s activity and play, “she sleeps most of the time and meows a lot at night. She doesn’t play – she’s an older cat”. How much of these behaviors is due to “normal” aging? How much is due to other medical conditions or a declining brain?

Cognitive Dysfunction Syndrome in cats or cat dementia refers to the decline in mental abilities associated with aging.

Cat dementia results from damage to the brain. As your cat ages, the the numbers of molecules called free radicals are no longer balanced out by the antioxidants in his body. These free radicals are reactive and cross the blood-brain barrier, damaging cells in the brain.

Changes in blood flow to the brain can also cause damage by starving the neurons of oxygen. High blood pressure, heart disease, anemia – are all conditions that alter the flow of blood to the brain.

How can we tell if our cats are undergoing mental decline? Is there anything we can do about it?

VISHDAAL – behavior changes

Changes in behavior can indicate if your cat’s mental state has declined. The acronym VISHDAAL summarizes the behavior changes we need to monitor in our senior cats, from the most prevalent (vocalizing) to least frequent (changes in learning and memory).

V = vocalization
I = changes in interaction with us and other pets
S = changes in sleep-wake cycle
H = house soiling
D = disorientation
A = changes in activity
A = anxiety
L = learning and memory

How do we sort out behavior changes due to disease and those due to declining mental capacity?

Changes in behavior signal the onset of cognitive decline but they may also arise from other health issues:

Cats with untreated high blood pressure or hyperthyroidism may meow at night (vocalizing).
Cats with untreated hyperthyroidism may be restless and beg us for food (changes in interactions and sleep).
Kidney disease can be accompanied by increased thirst and urination which may result in house soiling (house soiling)
Cats with osteoarthritis may have difficulty accessing the litter box (house soiling).

behavior changes: disease vs Dementia

Regular veterinary exams and diagnostics can identify medical conditions such as high blood pressure, hyperthyroidism, and osteoarthritis. If behavioral changes persist after treating these other medical conditions, your cat may have CDS or cat dementia.

Cat dementia is a “diagnosis of exclusion” – it is the diagnosis that remains after all the other possible diagnoses have been eliminated. Cat dementia will usually have a slow onset and behavioral symptoms will gradually get worse.

Cognitive Dysfunction (CDS) cannot be cured but management can reduce the symptoms and improve the Quality of Life for both you and your cat.

managing cat dementia

environmental enrichment/modification
dietary supplements
therapeutic diets
medication

Environmental enrichment/modification

In the early stages of cat dementia, enrichment increases mental stimulation, leading to the growth and survival of neurons, preserving the thinking processes. Enrichment should be tailored to the individual cat. For example, some cats prefer high places; others are “ground dwellers”. Arthritic cats will not have the range of motion of healthier cats but will still enjoy play that does not require lots of jumping.

Ways to enrich your cat’s environment:

play – interactive play and toys
scent enrichment – catnip, silvervine
food puzzles
motion – climbing (cat trees) and exploring (cardboard boxes)
supervised outdoor access

As CDS progresses…

Environmental changes become stressful and confusing. Cats with severe cat dementia need an environment that does not change much – daily routines and feeding schedules must be maintained. Litter boxes and feeding stations need to stay in the same place.

A cat with severe CDS may benefit from a “room of his own”, with easy access to his resources. Changes that need to be made must be done slowly. If you need to move a litter box or feeding station, do it gradually over a number of days so the cat can still find it.

Environmental modifications

Modifications to the environment of the cat with dementia should take into account the behavior that she is exhibiting.

Cats that constantly beg for food may benefit from a timed feeder at night or treat balls.
Cats with house soiling tendencies may need more litter boxes and ones that are easily accessed, with a lower entry for example.
Cats that become disoriented and confused may benefit from a night light and radio playing soft music.

Dietary Supplements

Dietary supplements in general seek to restore the balance between the activity of antioxidants in the body and the production of free radicals. Antioxidants give up electrons to the free radical, effectively “neutralizing” it so that it is no longer reactive. So, these supplements usually contain antioxidants.

SAMe: (S-adenosyl-methionine) aids in the production of glutathione, an antioxidant. When elderly cats were supplemented with SAMe, there was improvement in cognitive tests. SAMe is best used pro-actively – it is most effective in cats in the early stages of cat dementia.

Proprietary supplements containing vitamins, resveratrol (antioxidant), and fish oils are on the market but there is no clinical data testing cats for these at this time.

other supplements

Melatonin: hormone in the body that is thought to promote sleep. It also has antioxidant properties. Melatonin declines with age.

Pheromones (Feliway), Zylkene, Anxitane (L-theanine) may help reduce anxiety in cats that are disoriented and may promote sleep.

Therapeutic diets

Therapeutic diets containing antioxidants and fish oils have been shown to help cat dementia.

Feline Mature adult Hill’s Pet Nutrition
Purina Pro Plan Age 7+
Hills prescription diet j/d with fish oil for osteroarthritis

Diets that reduce anxiety may also help with cat dementia

RC Calm diets
Hill’s urinary support

Medications

Selegiline: licensed to treat dementia in dogs. Like the dietary suplements, it aims to reduce the production of free radicals. Selegiline stimulates the production of enzymes that eliminate free radicals.

Anxiolytics: Prozac, gabapentin and clonazepam are used to treat dementia by reducing anxiety.

boxes as enrichment for cats — Boxes can be source of enrichment for senior cats.

If you feel there has been a significant change in your cat’s behaviors, keep a journal or log and make sure to mention it at her next senior exam. Start the conversation with your vet about cat dementia and how to manage it!

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Caring for a blind cat

Posted on October 10, 2021October 18, 2021 by felinepurrspective_u3q4o6

You’ve stopped by the pet shelter and are interviewing the cats for adoption. You’re looking to adopt an adult cat – you feel your life is just too hectic to take on a pair of kittens. There is an orange male cat who seems friendly and rubs your outstretched hand in greeting. He is simply charming!

You find a shelter volunteer for more information. She asks you how you feel about caring for a blind cat. You do a double-take – the cat moves confidently around his enclosure, then turns and approaches you. Nothing about him makes you think he can’t see.

Blindness in cats can arise from a number of factors:

genetic condition present at birth
trauma to the eyes
cataracts due to aging or diabetes
detachment of the retina, resulting from high blood pressure, chronic kidney disease, or hyperthyroidism
infectious organisms, such as FeLV, FIV, can cause inflammation in the eye and lead to blindness.
untreated eye infections resulting from upper respiratory infections can also cause blindness

“keep an eye” on your cat’s eyes – see your vet if:

your cat is squinting
her third eyelids are swollen
her conjunctiva are red and swollen
there is discharge from her eyes – clear to greenish-yellow
her pupils are not the same size
she starts rubbing her eyes

Caring for a blind cat

Caring for a blind cat or cat who is gradually becoming blind is similar to caring for a “sighted” cat. Blind cats and “sighted” cats have the same environmental and emotional needs.

Blind cats adapt quickly to their surroundings. How do they do it? They rely on their other senses – smell, touch, and hearing – to get around.

The blind cat’s superpowers

superpower #1 – smell

Cats live in a landscape of odors. Cats have two ways of detecting odors in their environment:

the cells lining the nose and nasal cavity
the vomeronasal organ or VNO in the roof of the mouth

In the VNO, there are 3 types of “receptor proteins”. These receptor proteins respond to chemicals such as odors. We know more about the V1R protein than the other two.

Cats have 30 genetic variants of the V1R protein. Genetic variants refer to changes in the DNA sequence that makes up a gene. More genetic variants of the V1R protein allow cats to detect a greater variety of scents than say, dogs, who have only 9 genetic variants of this receptor protein.

Cats can associate certain odors/scents with a particular experience, place or other animal. For example, to a cat, another animal or person has a signature scent that the cat uses to identify that individual.

superpower #2 -TOUCH :THE WHISKER POSITIONING SYSTEM

Each whisker is embedded in a cluster of nerve endings located 3 x deeper in the skin than the surrounding hair follicles. Not only do whiskers alert your cat to the piece of furniture nearby, they alert him to changes in air currents, from say an open door or window.

Cats use their whiskers to navigate – whiskers help the cat pinpoint where she is relative to her surroundings – “can I fit behind this sofa?” Needless to say, a blind cat finds her whiskers crucial to getting around.

superpower #3 – hearing

Cats have one of broadest hearing ranges of all mammals. They are able to hear the high-pitched ultrasonic squeaks of mice and also the low-pitched tones of the human male voice.

Cats’ cone-shaped ears move independently of each other. Sounds will reach each ear at different times and allow the cat to pinpoint the source of the sound.

Watch as these blind cats track a bird.

CAT FRIENDLY HOMES FOR blind kitties

Setting up a cat-friendly home for a blind or partially blind cat is much the same as setting it up for a sighted cat. He will need multiple, separate litter boxes, feeding and water stations, and safe places to retreat to.

Your blind kitty will use his incredible sense of smell and ability to discriminate between scents, to navigate his environment. His hearing and whiskers will also alert him to the presence of other animals and objects. And just like any “sighted” cat, he should be introduced gradually to a new environment. (Yes, rearranging the furniture is a “new” environment.)

Alana Miller of Blind Cat Rescue & Sanctuary has some tips for caring for a blind cat:

Blind cats should only be indoor pets. Make sure there are no open pet doors, windows or other ways your cat could get outside. (A secure area like a catio can give your blind kitty a safe outdoor experience).
Make sure the house is safe. Keep cleaning chemicals, power cords or other potential tripping hazards out of your cat’s reach. Be aware of spaces he could explore and get stuck in like behind washer/dryers.
Stairs. Make sure you’re with your cat the first few times she uses the stairs until you’re sure…she knows where they are and is able to navigate them.
Know where your blind cat is. He can’t see you and may not know he’s under your feet… you don’t want to step on him by accident.
Let your blind cat know that you are going to touch her. A blind cat can’t see your hand coming … she might startle when you touch her. As you approach, make sure you rub your fingers together or make a gentle noise with your hand to alert her.

Whether you adopt a blind kitty or your older kitty has vision loss, remember your blind cat has the same needs as sighted cats. With some modifications, you can provide a safe and enriching environment for your blind cat.

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How do I know if my cat has arthritis?

Posted on June 6, 2021 by felinepurrspective_u3q4o6

Arthritis refers to inflammation and stiffness in the joints. As humans and cats age, the protective cartilage that cushions the ends of the bones wears down. Osteoarthritis in humans most often affects our hands, knees, hips and spine; in cats, it is most prevalent in the hip, hock and elbow joint.

HOW DO I KNOW IF MY CAT HAS ARTHRITIS?

Your cat can’t tell you verbally that he is painful. You must watch his body language and behavior.

BODY LANGUAGE:

Do you detect a limp or stiffness as he moves?
Is your cat more grumbly, maybe even aggressive when you groom or pet him?
Is she hunched-up instead of curled-up when sleeping?

BEHAVIOR:

Is she just not as active?
Does he still jump up on the bed, chairs, or counters?
Does he still use his scratching posts?
Does she still climb up the cat tower?
Does she still play with toys?

If your cat is still doing his regular cat things, we now need to consider HOW he is doing those things.

JUMPING UP AND DOWN

Does she still spring up on tables, counters, landing gracefully on all four feet? Or, does he pull himself up with his front claws to get on the bed?
Does she jump on a chair first and then go to the table instead making one jump from the floor?
Does he go down in one jump or in stages?

UP AND DOWN STAIRS

Does he run smoothly up and down the stairs or does he go up and down the stairs a step at a time? Does he “bunny-hop” up with his back legs?
Does she stop for a break halfway?

PLAYING WITH TOYS

When he swats his catnip mouse about, is he still able to pass it smoothly from paw to paw or does he seem slow and stiff?
Can she still snatch the toy in mid-air?

OTHER THINGS TO WATCH FOR:

Is she not grooming as much as before? Are you noticing some mats forming in her coat?
Any litter box accidents?
Is his appetite still good?

If you answer “yes” to some of these questions, it is possible that your cat has arthritis and may be having some pain and stiffness in her joints.

Pain and discomfort that happens while you are doing something usually results in your avoiding that activity. Chronic pain can affect all the systems in the body, affecting appetite, sleep, and how well your bowels work. Treating your cat’s arthritis will improve his quality of life.

My cat has arthritis – WHAT CAN I DO ABOUT it?

A veterinary exam is needed to diagnose arthritis and to come up with a treatment plan.

Cats can be difficult to assess in the veterinary hospital. They are out of their environment at the hospital and are reluctant to play with toys or even just to move around. This is where, you, the cat guardian, can help your vet help your feline friend.

Smartphones nowadays can take high resolution video. We often have our phones with us, so take some video of your kitty going up the stairs, jumping up on the bed, or jumping down from her favorite spot. You can send the video to your vet to help with the diagnosis and treatment plan for your cat.

TIPS FOR TAKING VIDEOS

Take the video with your phone in the “landscape” orientation. If you video with the phone vertical, the video frame will have black borders on either side.
Have “LOTS” of light. The more light the better particularly in stairwells. Bring some of those floor lamps in there.
Most phone camera default to “autofocus”. You may need to FOCUS your phone. Tap on the screen where your “subject” (your cat ) is or will be – your camera will focus on that area; some exposure controls may also show up; adjust as needed.

MY CAT HAS ARTHRITIS – WHAT IS THE TREATMENT?

If your cat is diagnosed with arthritis, your vet can recommend a treatment plan. It may include:

pain medications
dietary supplements
weight loss
environmental changes
exercise

It is great that you are being proactive with your cat’s health! Arthritis is part of getting old but let’s try to make your cat’s senior years as “golden” as possible. You can find out more about your cat and arthritis at the Osteroarthritis Checklist for Cats.

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Exercising Your Cat

Posted on May 30, 2021 by felinepurrspective_u3q4o6

Keeping active physically has a lot of benefits for people. It helps your mind work better – you learn things more easily. Physical exercise helps increase your muscle mass and strength. It also tends to induce a positive mood or emotional state.

Exercising your cat can give your cat the same boost we get from physical activity. Unfortunately, just like us, it is easy for them to become couch potatoes.

My 16 year old, Athena, is the equivalent of an 80 year old person. She has developed osteoarthritis and chronic kidney disease. To help with the arthritis, I have provided her with steps to get places and litter boxes with lower entrances. This winter I bought her a heated bed which she really likes. I noticed, however, that she was spending an awful lot of time in this bed and not moving around as much.

Although heat increases blood flow and makes connective tissue temporarily more flexible, it also stimulates inflammation and swelling. So some heat is good for comfort but I wanted to reduce the inflammation associated with Athena’s arthritis and cheer her up a bit!

Exercising your Cat – A good Rx

Exercise reduces inflammation: Your body’s cells produce proteins called cytokines that regulate immunity and inflammation. Humans with arthritis who exercise produce more cytokines that reduce inflammation. Cells in cat’s bodies produce similar cytokines so exercise can also reduce inflammation in cats.
Exercise strengthens the muscles that surround joints making movement easier and less painful.
Exercise improves mood, memory, reduces anxiety and helps the GI tract to function better.

The TAKEAWAY: Daily play (exercise) is good for cats of all ages!

Here are some exercises to work into your cat’s daily play time. Make sessions short and positive and work at your cat’s own pace.

Cat sitting up — Gus sits up on his hind legs.

More Please!: Holding a treat or toy above your cat’s head, encourage him to sit up with his front feet off the ground for a few seconds. This is good for kitty’s core muscles.

Catch the bird: A feather toy on a wand can encourage your cat to “stand up”, engaging his core muscles.

Catnip/silvervine Roll: If your cat enjoys catnip or silver vine, by all means indulge her. The catnip response lasts less then 10 min and often involves rolling around, which is good for kitty’s core muscles.

Cat walking on cushions — Athena has to shift her weight and balance to walk across the cushions.

Balancing: Have your cat walk over an uneven surface such as a bed or several pillows. She will need to shift her weight to keep her balance, exercising her legs, core, back muscles and more. She can follow a feather toy, target stick with food on the end or a trail of treats!

Strengthen back legs: Following a string up the stairs or cat tree will put more weight on the rear legs. Alternate exercise: have kitty stand with his front legs up on some cushions or books so more of his weight is on his rear legs for a few seconds. Start low at first. Pet his head and reward him.

Strengthen front legs: Following a toy or string (slowly) down the stairs or cat tree will put more weight on your cat’s front legs. Alternate exercise: you can use a soft towel or blanket around her lower belly to lift her hind legs, putting more weight on the front legs for a few seconds. Start in a stationary position. Work up to going forward. Head rubs and treats will make this fun for your cat!

Cardio! Do a little play with the laser pointer, wand toys or shoelaces. Make sure to put these toys away when the play session is done.

Exercising your cat will help her to be happier and feel better. Less pain and better mood translates to better relationships for your cat with people and other pets! Remember, this does not have to take a lot of time: 10-15 minutes should do the trick!

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Caring for Your Older Cat

Posted on January 31, 2021 by felinepurrspective_u3q4o6

Cats are considered mature at 7-10 years, senior at 11-14 years (human age 60-72 years) and Super Senior at 15+ years (human age 76+ years) (Your cat’s age in human years). Here are some tips for caring for your older cat.

Once past 2 years, cats age at a rate of 4 years per every human year. Regular veterinary visits are beneficial for your Mature, Senior and Super Senior cats. Good veterinary care can make your older cat’s senior years golden years.

Mature, Senior and Super Senior cats have the same needs as younger animals.

safe place
multiple and separated resources – food, water, litter boxes
opportunity for play
positive, consistent and predictable human interaction
an environment that respects the cat’s sense of smell

Caring for Your Older Cat: The “Senior” Cat Friendly Home

Safe Places

Steps to bed for older cat — A step ladder gives Athena easy access to the bed.

An older cat needs private and secure places to retreat to, to rest and take a break from household activity. Steps or ramps provide easy access to higher places. A heated bed with extra padding can be a real hit for an older cat stiff from arthritis.

Resources – Food, Water, Litter Boxes

Ice cube tray as a food puzzle — This older cat is getting lunch from an ice cube tray.

Still a hunter at heart, your older cat is designed to eat small meals, frequently during the day. Feeding stations throughout the house will encourage her to prowl and “hunt” her food, stimulating her physically and mentally.

Your old cat will most likely drink more than he did when he was young. Locate water sources throughout the house. If your cat seems stiff, try raising his food and water up so that he does not have to crouch down as much to eat and drink.

Litter Box from storage tote — A storage tote has been repurposed as a litter box. The front opening is low and was cut with heavy duty shears and a hacksaw. A trash can for scooping is nearby.

THE LITTER BOX

Large enough for your cat to turn around.
Entrance has a low sill for easy access.
On each floor of the house
In areas that are secluded and private
Finer textured litter may be more comfortable for older kitty paws.

Play is still important

Older cats can still can benefit from swatting at a wand toy or chasing treats. Daily play time close to early morning or early evening mimics the cat’s natural rhythms – prey is most active at these times.

Human Interaction

A familiar predictable routine reduces anxiety for all cats. Caring for your older cat should include grooming as well as play time. Grooming becomes more challenging for older cats as their flexibility decreases.

Make grooming sessions frequent and short.
Cats often groom after eating. This is a good time to gently comb or brush the older cat.
Regular nail trims are important for older kitties – the nails of older cats can sometimes grow into their paw pads, which is painful.
Older cats still need access to scratching areas – horizontal and angled scratchers may be easier for them to use

Your Cat’s Sense of Smell

Cats have a sense of smell that is 14x more sensitive than ours.

Diffusers containing facial pheromones placed near some of your older cat’s resting places will convey the messages of familiarity and safety
Scratching releases pheromones from glands in your cat’s paws that help mark his territory- have scratchers available to your older cat
Avoid using scented litters and strong smelling cleaners

Outdoor Access

SAFE outdoor access is stimulating for older cats as well as young cats. Your cat may like some supervised outdoor time with you – the daily “walk” can provide quality time for both cat and owner.

IF you are lucky enough to live in a quiet neighborhood or have access to a quiet park, a cat stroller can get you and your old friend out.

Get her used to the stroller first – offer some food in it, let her nap in it
Start with SHORT walks in QUIET places at QUIET times.
Increase the walking time IF she is enjoying it.